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So far, we have only learned the results of preclinical studies. Spike Ferritin Nanoparticle (SpFN) elicited a very good immune response in immunized animals (monkeys). Researchers at Walter Reed Army Research Institute (WRAIR) also reported that the experimental vaccine appears to provide intense protection against novel variants that are also worrisome. SARS-CoV-2 and against other coronaviruses (eg SARS-CoV-1).
– We wanted to create a vaccine against pancreatic virus — a vaccine that would provide safe, effective and lasting protection against many variants of SARS-CoV-2 and other strains of the coronavirus — says Dr. Kavon Modgarad, co-founder of the preparation.
The results of preclinical studies in monkeys have just been published in the journal Science Translational Medicine. Phase 1 clinical trials, already involving humans, began in April 2021. Preliminary data is expected later this year. 72 people participated in this phase of the research.
Scientists expect to find an answer to the question of whether this immune response is good vaccinationAs observed in animals, it is also possible in humans. In addition, they will be able to compare the immunological profile of the SpFN preparation with the immunogenic properties Vaccines currently in use against COVID-19.
SpFN vaccine contains ‘football-shaped’ particles
It is a SpFn nanoparticle vaccine based on the ferritin platform. Ferritin is a naturally occurring and ubiquitous iron transport protein. The SpFn vaccine should be a new generation of preparations that will protect us from many types of coronaviruses.
Our vaccine is distinct from other preparations for the Covid-19 virus. The vaccine makers demonstrate that repeated, regulated presentation of the coronavirus spike protein (spike protein) onto a multifaceted nanoparticle can stimulate the body’s immune response in a way that translates into much broader immunity.
Figuratively speaking, the experimental vaccine contains particles that have 24 sides, like a soccer ball (the “classic” ball actually has 32 sides). A different spike protein (from different types of coronavirus if different) can be incorporated into each wall of the molecule. Thus, when such a vaccine is given, the immune system is stimulated to produce a variety of neutralizing antibodies.
US military labs have another “candidate” for a COVID-19 vaccine. It is a preparation containing ferritin nanoparticles that can “bind” the receptors found in high SARS-CoV-2. This experimental formulation is no longer as versatile as the SpFn pancoronavirus vaccine. However, early research results show that it is very effective with most SARS-CoV-2 variants.
Resources: MedicalXPress.comAnd Translational Medicine SciencesAnd Army
